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Objective
This study aimed to estimate population‐level prevalence of obesity and severe obesity for New York City youth and examine the most recent trends over time.
Methods
All public school youth in grades kindergarten through eighth (K‐8) (2011‐2012 through 2016‐2017) with valid weight and height measures were included (N = 1,137,782 unique students; 3,720,297 observations). Age‐ and sex‐specific...
Objective
This study sought to determine improvements in mental and physical health–related quality of life (HRQOL) following bariatric surgery in Medicaid and commercially insured patients.
Methods
Using data from the Longitudinal Assessment of Bariatric Surgery, an observational cohort study of adults undergoing bariatric surgery (2006‐2009), changes in Short Form 36 mental component summary...
Objective
This study aimed to determine whether controlling maternal gestational weight gain (GWG) influences adipose tissue distribution at 1 year postpartum.
Methods
Women with overweight or obesity (n = 210, BMI ≥ 25 or ≥ 30) were randomized to a lifestyle intervention (LI) designed to control GWG or to usual obstetrical care (UC). Measures included anthropometry, whole‐body magnetic resonance...
Objective
Interleukin (IL)‐1β is involved in obesity‐associated inflammation and in the pathogenesis of type 2 diabetes (T2D) mellitus. Our aim was to correlate serum IL‐1β and caspase‐1 levels with weight loss, glucose metabolism, and insulin resistance (IR) after bariatric surgery.
Methods
A total of 32 patients with morbid obesity and T2D (Ob‐T2D) and 29 patients with morbid obesity and normal...
Objective
The aim of this study was to investigate alterations in functional connectivity (FC) within and interactions between resting‐state networks involved in salience, executive control, and interoception in participants with obesity (OB).
Methods
Using resting‐state functional magnetic resonance imaging with independent component analysis and FC, alterations within and interactions between...
Objective
Early life physical activity may help prevent obesity, but objective quantification in infants is challenging.
Methods
A total of 506 infants were examined from 2013 to 2016. Infants wore accelerometers for 4 days at ages 3, 6, 9, and 12 months. Daily log‐transformed physical activity counts were computed, averaged, and standardized across assessments. A linear mixed model was used to...
Objective
Rural black communities bear a disproportionate burden of obesity. To increase reach among underserved groups, community‐based weight loss and maintenance interventions are crucial.
Methods
The Diabetes Prevention Program (DPP) was adapted for rural black adults of faith to create The Wholeness, Oneness, Righteousness, Deliverance (WORD) trial, a group‐based, community health worker–delivered...
Objective
Adipose tissue plays a key role in obesity‐related metabolic dysfunction. MicroRNA (miRNA) are gene regulatory molecules involved in intercellular and inter‐organ communication. It was hypothesized that miRNA levels in adipose tissue would change after gastric bypass surgery and that this would provide insights into their role in obesity‐induced metabolic dysregulation.
Methods
miRNA...
Objective
Previous studies have shown additive weight loss when intensive behavioral therapy (IBT) was combined with weight‐loss medication. The present multisite study provides the first evaluation, in primary care, of the effect of the Centers for Medicare and Medicaid Services–based IBT benefit, delivered alone (with placebo) or in combination with liraglutide 3.0 mg.
Methods
The Satiety and...
Objective
Restricting dietary methionine to 0.17% in male mice increases energy expenditure, reduces fat deposition, and improves metabolic health. The goal of this work was to compare each of these responses in postweaning male and female mice and in physically mature male and female mice.
Methods
Methionine‐restricted (MR) diets were fed to age‐matched cohorts of male and female mice for 8 to...
Objective
The aim of this study was to evaluate the effect of a policy to deliver at 39 weeks for class III obesity.
Methods
This was a retrospective cohort study of women with class III obesity delivering at ≥ 37 weeks before (May 2012 to April 2014) and after the policy (September 2014 to August 2016). The primary outcome was the cesarean rate. Secondary outcomes included maternal morbidities...
Objective
Obesity is responsible for a huge burden of suffering and social costs, and yet many patients lack access to evidence‐based therapies. The diagnostic term “obesity” and inadequate International Classification of Diseases(ICD) codes contribute to suboptimal efforts to prevent and treat obesity as a chronic disease. The goal of this review is to develop a medically actionable classification...
Objective
Quantifying risk for cardiovascular disease (CVD) events among adolescents is difficult owing to the long latent period between risk factor development and disease outcomes. This study examined the 30‐year CVD event risk among adolescents with severe obesity treated with and without metabolic and bariatric surgery (MBS), compared with youths with moderate obesity, overweight, or normal...
Objective
Insulinlike growth factor II (IGF‐II) regulates metabolism and growth. In humans, both positive and negative relationships have been reported between serum IGF‐II levels and obesity. This study assessed the relationship between serum IGF‐II levels and BMI and determined whether IGF‐II levels predict weight gain.
Methods
Serum samples were available from 911 American Indians with a recorded...
Objective
Previous studies have revealed decreased mitochondrial respiration in adipocytes of obese mice. This study aimed to identify the molecular underpinnings of altered mitochondrial metabolism in adipocytes.
Methods
Untargeted proteomics of mitochondria isolated from adipocytes and metabolite profiling of adipose tissues were conducted in diet‐induced obese (DIO) and lean mice. Subcutaneous...
Objective
The hypertriglyceridemic waist (HTGW) phenotype is characterized by abdominal obesity and high levels of triglycerides. In a cross‐sectional assessment of PREDIMED‐Plus trial participants at baseline, HTGW phenotype prevalence was evaluated, associated risk factors were analyzed, and the lifestyle of individuals with metabolic syndrome and HTGW was examined.
Methods
A total of 6,874 individuals...
Objective
This meta‐analysis aimed to assess the effect of mobile application (app) interventions on weight loss in patients with type 2 diabetes.
Methods
Electronic databases were searched for randomized controlled trials examining the use of mobile app interventions with outcomes on weight loss evaluated by body weight or other measures such as BMI or waist circumference. A random‐effects model...
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